There are current project and strategic initiatives within Northern Health which you can get involved in as junior doctors.
Research Leads
| Division | Research Lead | Contact Email |
| Allied Health | Adam Semciw | Adam.Semciw@nh.org.au |
| Cancer Services | Belinda Lee & Prahlad Ho | Belinda.Lee@nh.org.au |
| Diagnostic Services | Hui Yin Lim &
Prahlad Ho |
HuiYin.Lim@nh.org.au |
| Emergency Services | Bill van Gaal (Cardiology),
Joe Rotella (ED), Angaj Ghosh (ICU) & David Crosbie (ICU) |
William.vanGaal@nh.org.au |
| Medicine | Tim Pianta | Timothy.Pianta@nh.org.au |
| Sub-Acute | Sandra Brown | Sandra.Brown3@nh.org.au |
| Surgery | Russell Hodgson & Darren Lowen | Russell.Hodgson@nh.org.au Darren.Lowen@nh.org.au |
| Nursing | Annabel Milonas | Annabel.S.Milonas@nh.org.au |
| Women’s and Children’s | Lisa Hui | Lisa.Hui@nh.org.au |
| Pharmacy | Jeff Khoshaba | Jeff.Khoshaba@nh.org.au |
| Hospital Without Walls | Rebecca Jessup | Rebecca.Jessup@nh.org.au |
| Mental Health | Gary Ennis | Gary.Ennis3@nh.org.au |
Research Projects at Northern Health
| Clinical Division | Project Title |
| Emergency Services
|
A randomised blind placebo controlled trial of hydrocortisone in critically ill patients with septic shock (ADRENAL) |
| Nebulised heparin for lung injury. A multi-centre, randomised, double blind, placebo controlled trial (CHARLI) | |
| Sedation practice in intensive care evaluation: SPICE III: A prospective multicentre randomised controlled trial of early goal directed sedation compared with standard care in mechanically ventilated partients in intensive care (SPICE) | |
| National study of family experiences of organ and tissue donation (Donor Family Study Waves 2-4) | |
| Proton Pump Inhibitors vs. Histamine-2 REceptor Blockers for Ulcer Prophylaxis Therapy in the Intensive Care Unit (PEPTIC) | |
| The Augmented versus Routine approach to Giving Energy Trial: A randomised controlled trial. (The TARGET Nutrition Study) |
|
| STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRTAKI): A MultiCentre, Randomized, Controlled Trial |
|
| Responding to the needs of Children/Young people visiting patients in the intensive care unit | |
| Factors associated with patients undergoing Medical Emergency Team (MET) review at a metropolitan teaching hospital: a multi-faceted audit of antecedent factors and patient outcomes Short Title:MET Call Audit | |
| Intensive Care outcomes from epidemic asthma following a thunderstrom | |
| Association between Time to Infection Management and In-hospital Mortality in the Northern Hospital ICU | |
| Panadeine Forte Audit | |
| Barriers and facilitators to framing in-hospital goals of patient care: physician’s perceptions – a mixed methods approach. | |
| Monitoring and Evaluation of the Victorian State Trauma System – Victorian State Trauma Registry (VSTORM & VOTOR) | |
| The Victorian Ambulance Cardiac Arrest Register (VACAR) | |
| Knowledge Translation in Australasian Paediatric Acute Care Settings: a multi-centred, cluster, randomised controlled trial comparing a tailored, theory informed Knowledge Translation intervention versus passive dissemination of a bronchiolitis guideline. PREDICT KT Study | |
| Reduction of Oxygen After Cardiac Arrest: The EXACT study | |
| The use of intramuscular ketamine by paramedics in the management of the severely agitated patient | |
| “Exploring the delivery of education in the clinical setting to improve paediatric triage education in Australian emergency departments” | |
| Ed Medicine Screening tool study | |
| Northern Emergency Department Step on Sepsis | |
| Prospective, multi centre, international registry of male and female patients newly diagnosed with atrial fibrillation. GARFIELD-AF | |
| Victorian Cardiac Outcomes Registry (VCOR) | |
| PARAGON – A multicenter, randomized, double-blind, parallel group, active-controlled, study to evaluate the efficacy and safety of LCZ696 compared to valsartan, on morbidity and mortality in heart failure patients (NYHA Class II-IV) with preserved ejection fraction | |
| Victorian Cardiac Outcomes Registry (VCOR) – Heart Failure Snapshot | |
| Colchicine in Patients with Acute Coronary Syndromes – the COPS trial | |
| A clinical evaluation of the Medtronic Polymer-Free drug-eluting stent system in de novo native coronary artery lesions(RevElution) | |
| A phase III, double-blind, randomized placebo-controlled study to evaluate the effects of dalcetrapib on cardiovascular (CV) risk in a genetically defined population with a recent Acute Coronary Syndrome (ACS): The dal-GenE trial DAL-301 (Dal-GenE) | |
| Ivabradine in the prevention of Peri-operative Myocardial Injury (IPMI) | |
| PROTECT-ICD Trial: Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-defibrillator Implantation to Prevent Tachyarrhythmia following Acute Myocardial Infarction | |
| DE novo Combination allopurinolthiopurine vs standard thiopurine in IBD patients Escalating to immunomodulators: a Randomized controlled trial (DECIDER study) |
|
| A phase III randomised, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with preserved Ejection Fraction (HFpEF). |
|
| The COlchicine for COronary Plaque MOdification in Acute Coronary Syndrome study. (COCOMO-ACS) study |
|
| A phase III randomised, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with reduced Ejection Fraction (HFrEF). |
|
| A Phase 3, Multicentre, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome Protocol #: CSL112_3001 [the ApoA-I Event ReducinG in Ischaemic Syndromes II (AEGIS-II) Study | |
| Imaging of Coronary Plaques in Subjects Treated With Evolocumab (HUYGENS) |
|
| Optical Coherence Tomography Assessment for Acute Coronary Events in Type 2 Myocardial Infarction/Myocardial Injury | |
| The Massachusetts General Hospital Optical Coherence Tomography Registry (The MGH OCT Registry) | |
| Improving the quality of emergency care for women with heart attacks |
| Clinical Division | Project Title |
| Medicine and Subacute Services | Identifying risks for Thunderstorm Asthma in Seasonal Allergic Rhinitis (TAISAR) cohort study |
| Does music listening during pulmonary rehabilitation in individuals with chronic obstructive pulmonary disease (COPD) improve outcomes? A mixed methods study | |
| Patients’ Perspectives on the Use of a Pulse Oximeter at home. | |
| Point prevalence of diabetes & hyperglycaemia in hospitalised patients at Northern and Melbourne Health | |
| PREDICT UC: Optimising Infliximab Induction therapy for Acute Severe Ulcerative Colitis – A Randomised Controlled Trial |
|
| I6T-MC-AMAN: A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and. Biologic-Failed Patients with Moderately to Severely Active Ulcerative Colitis (LUCENT 1) |
|
| I6T-MC-AMBG: A Phase 3, Multicentre, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Maintenance Study of Mirikizumab in Patients with. Moderately to Severely Active Ulcerative Colitis (LUCENT 2) |
|
| Australian Stroke Clinical Registry (AuSCR) | |
| Fatigue After Stroke Trial (FAST): A randomised controlled study | |
| ATTUNE- ATrial fibrillation in sTroke: Utility of Neuroimaging Evaluation | |
| Participation in Safe Implementation of Treatments in Stroke (SITS) registry | |
| Retinal small vessel abnormalities and increased vascular risk | |
| The identification of novel genes for inherited renal disease, and understanding how these mutations cause disease: Optimisation of the clinical pathway | |
| Australian Follow-up Tracking and Enhancing Recovery after Acute Kidney Injury (AFTER – AKI) | |
| Early needs assessment of adult patients in acute care (Subacute) | |
| Memory and Mood in OSA treatment study (Subacute) | |
| Reducing the impact of aphasisa in stroke patients & their caregivers a year post onset via a brief early intervention (Subacute) | |
| The impact of health assets on outcomes for hospitalised older adults: Development and validation of a health assets index for hospitalised older adults. | |
| Does Electronic Prescribing Lead to Increased Prescribing Errors in the Elderly? A Pilot Study of Intern Prescribing Accuracy in Electronic versus Manual Systems. (Subacute) |
|
| Preventing Avoidable Hospital Admissions for People with Dementia- An Evaluation of Carer and Staff Perspectives (Subacute) | |
| A Phase II randomised, double-blind, placebo-controlled pilot study to assess the efficacy and safety of BNC210 in hospitalised elderly patients with agitation (Subacute) |
|
| Evaluating and monitoring the Goals of Patient Care Summary (Subacute) | |
| Exploring the needs of informal carers of people with advanced Parkinson’s disease: a pilot study (Subacute) | |
| Effectiveness of a Falls Prevention Intervention in Medical Inpatients Using Lean Thinking Methodology (Subacute) | |
| The association between a secure GEM ward’s aggressive behaviour (RAGE) score and unplanned nursing leave (Subacute) | |
| Resident- to resident elder mistreatment (R-REM) in resifential agend care (Subacute) | |
| Prosthetic joint infection in Australia and New Zealand observational (PIANO) study | |
| Establishing outcomes for people not regularly attending HIV care |
| Clinical Division | Project Title |
| Cancer Services | Establishment of a Tissue Bank to collect, store and distribute data, blood and tissue for ethically approved research projects |
| A Phase III trial evaluating the role of continuous letrozole versus intermittent letrozole following 4 to 6 years of prior adjuvant endocrine therapy for postmenopausal women with hormone receptor positive, node poitive, early stage breast cancer (SOLE trial) | |
| A randomised, multi-center, double-blind phase 3 study of PD-0332991 (oral CDK 4/6 INHIBITOR) plus letrozole versus placebo plus letrozole for the treatment of postmenopausal women with ER (+), HER2 (-) breast cancer who have not reeived any prior systemic anti-cancer treatment for advanced disease. | |
| PALLAS: PALbociclib CoLlaborative Adjuvant Study A randomized phase III trial of Palbociclib with standard adjuvant endocrine therapy versus standard adjuvant endocrine therapy alone for hormone receptor positive (HR+) / human epidermal growth factor receptor 2 (HER2)-negative early breast cancer |
|
| LEAD – Lung cancer diagnostic and treatment pathways: a comparison between CALD and Anglo-Australian patients | |
| Establishing a biobank of colorectal and pancreatic cancer models for the pursuit of personalised therapies | |
| Pancreatic cancer: Understanding Routine Practice and Lifting End results (PURPLE) A Prospective Pancreatic Cancer clinical registry | |
| Lung Cancer Clinical Quality Registry | |
| Assessing Predictive and Prognostic Biomarkers in Pancreatic Cancer | |
| Tumour DNA Analysis Informing Adjuvant Chemotherapy in Stage III Colon Cancer: A Multicentre Phase II/III Randomised Controlled Study (DYNAMIC-III) |
|
| How oesophageal cancer is diagnosed and treated in Victoria: understanding practice and treatment decisions. | |
| Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Locally Advanced Rectal Cancer: A Multicentre Randomised Study (DYNAMIC-Rectal) |
|
| Evaluation of Global Coagulation Assays in patients with active malignancy and/or undergoing chemotherapy | |
| The AvR-CHOP study | |
| Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Stage II Colon Cancer (DYNAMIC II) |
|
| Treatment of Recurrent and Advanced Colorectal Cancer (TRACC): A prospective multi-site registry |
|
| A Phase 3, Double-blind, Randomized Study of BGB-290 versus Placebo as Maintenance Therapy in Patients with Inoperable Locally Advanced or Metastatic Gastric Cancer that Responded to Platinum-based First-line Chemotherapy | |
| DNA Analysis Informing Adjuvant Chemotherapy in Early Stage Pancreatic Cancer: A Multicentre Randomised Study (DYNAMIC-Pancreas) | |
| Upper Gastrointestianal Cancer Registry | |
| Healthy Living after Cancer (HLaC) – a telephone-delivered healthy lifestyle coaching program for cancer survivors | |
| Evaluation of the implementation of the use of My Cancer Care Record (MY CCR) | |
| A Population-Based Prostate Cancer Outcomes Registry Victoria (PCORVic) | |
| The role of CxBladder in identifying urothelial carcinonma in haematuria patients and it’s place in triaging of cystoscopic investigation of haematuria | |
| BioGrid Australia – Australian Cancer Grid (ACG). | |
| Thrombotic Thrombocytopenic Purpra (TTP) Registry | |
| Response post tyrosine Kinase Inhibitor: assessment of sensitivity and therapeutic response to next line therapy in CML. The Australian RESIST Study | |
| A randomised, double-blind, multi-center study of denosumab compared with zoledronic acide (zometa) in the treathment of bone disease in subjects with newly diagnosed multiple myeloma (Denosumab 90090482) | |
| Myeloma & Related Diseases Registry (MRDR) | |
| Evaluation of new Biomarkers of thrombosis in a normal population as well as anticoagulated and hypercoagulable states | |
| Prospective VTE biomarker Study | |
| Global anticoagulant registry in the FIELD observing treatment and outcomes in patients with treated acute venous thromboembolic events in the real world (GARFIELD-VTE) | |
| An Australian, phase III, multi-centre, randomised trial comparing lenalidomide consolidation Vs no consolidation with chronic lymphocytic leukaemia and residual disease following induction chemotherapy (RESIDUUM (CLL6) | |
| A prospective, open-label, multicenter, randomised phase III trial to compare the efficacy and safety of a combined regimen of obinutuzumab and GDC-0199 (ABT-199) versus obinutuzumab and chlorambucil in previously untreated patients with CLL and coexisting medical conditions | |
| The donation, collection, storage and usage of blood and bone marrow samples for the investigation of CD4+ T cell fate in plasma cell dyscrasia. | |
| Evaluation of global coagulation assay parameters in normal and thrombocytopenic populations | |
| Evaluation of global coagulation assays in patients with High Risk cardiovascular Disease risk factors | |
| The Australasian Leukaemia & Lymphoma Group National Blood Cancer Registry and Biorepository | |
| A Phase III, double-blind, placebo-controlled, multicentre, randomized study of Pracinostat in combination with Azacitidine in patients 18 years with newly diagnosed acute myeloid leukemia unfit for standard induction chemotherapy. |
| Clinical Division | Project Title |
| Surgery | Acupressure for PONV (Stages 2 – 4) |
| Endoscopic Polypectomy on Clopidogrel; a randomized controlled trial | |
| Cyanoacrylate glue vs tacks in fication for laparoscopic inguinal hernia repair | |
| Transition, threshold concepts and troublesome knowledge in medical education: Hurdles in becoming an intern doctor | |
| Is laparoscopy safe in pregnancy? Perioperative and obstetric outcomes of laparoscopic surgeries during pregnancy | |
| Retrospective review of upper gastrointestinal bleeding | |
| Are we choosing wisely at Northern health for inguinal hernia repair? | |
| Barrett’s Oesophagus: Review of patient outcomes and guideline adherence | |
| “Investigation of barriers and areas for improvement in plastic surgery care between General Practices in the Northern catchment and The Northern Hospital.” | |
| Critical Care Use following elective primary hip and Knee joint | |
| Laparoscopic Cholecystectomy Video Assessment Study | |
| A multi-centre survey to evaluate the outpatient clinic experience in surgical education and training using cloud-based resources | |
| Acupressure for peri-surgical care: Implementing effective treatments to improve post-operative nausea and vomiting Short Title: Reducing post-surgical nausea and vomiting | |
| Australian Brest Device Registry (ABDR) | |
| “Clinical outcome and risk factors for failure in patients with a late acute prosthetic joint infection | |
| “Clinical outcome and risk factors for failure in patients with a late acute prosthetic joint infection” | |
| Joint replacement following hip fracture | |
| “Epidemiology, Management and outcomes of Traumatic Knee Dislocations (A VOTOR Report) Short Title: Traumatic Knee Dislocations” | |
| In Vivo Reproducibility of the KneeKG in Patients of Different BMIs | |
| Validation of Satisfaction Visual Analogue Score for Patient Satisfaction in Post Total Knee Arthroplasty Patient. Short Title: Validation of Satisfaction VAS in post TKA patient | |
| Evaluation of Biomet patient specific instrumentation in patients undergoing total shoulder replacement | |
| Patella Stabilisation surgery patient outcome scores | |
| Outcomes of operated ankle fractures treated with early weight bearing vs. Six weeks of plaster. | |
| ANZHFR – Australia & New Zealand Hip Fracture Registry | |
| Ideal positioning of elevated-rim acetabular liners in primary total hip replacements | |
| Knee Kinematics in patellofemoral dislocation patients | |
| Knee Kinematics in patients with ACL tear | |
| Medial pivot versus posterior stabilising total knee prosthesis: a comparison of early clinical and functional outcomes and patient satisfaction | |
| Surgery for Olecranon Fractures in the Elderly: a randomised controlled trial of operative vs. Non-operative treatment (SOFIE) | |
| Northern Health Orthopaedic Outcomes – Hip | |
| Anatomical features of the knee patellofemoural dislocation: An MRI based study | |
| Northern Health Orthopaedic Outcomes – Knee | |
| Prospective outcomes after creation of arteriovenous fistula (POCAF) | |
| TRAMOD | |
| The Perioperative ADministration of Dexamethasone and Infection – The PADDI trial | |
| Reduction Of Chronic Postsurgical Pain with Ketamine ROCKet Trial | |
| Does a correlation exist with either ROTEM or Thrombin Generation Assay and a venous thromboembolism risk assessment chart? The CLOT Study. | |
| “A feasibility study to determine if ROTEM may be used to correlate a postpartum venous thromboembolism risk score” | |
| Binational Colorectal Cancer Audit (VIC) – BCCA (VIC) | |
| Cultural perspectives on colorectal cancer screening and the reporting of bowel symptoms – the Arabic-Australian Story. Short title: Bowel health – the Arabic perspective | |
| The role of deep neuromuscular blockade in an ERAS programme for colorectal surgery. |
| Clinical Division | Project Title |
| Women’s & Children’s Health
|
Pilot evaluation of global coagulation assays in maternal and umbilical cord blood |
| Improving management of mastitis in breastfeeding women | |
| THE CROSS-COUNTRY ULTRASOUND STUDY – CROCUS | |
| Harnessing Neuroplasticity to Improve Motor Performance in Infants with Cerebral Palsy: a Pragmatic Randomized Controlled Trial (GAME Trial) |
|
| Northern Centre for Health Education and Research (NCHER) Reproductive Health Biobank | |
| Ronald McDonald Family Rooms: Understanding their outcomes for families with hospitalised children | |
| Antenatal corticosteroid therapy – do neonatal outcomes match expectations? The Northern Health experience | |
| “Meconium stained amniotic fluid- how great a risk is it? A population based study in the Northern Region, examining relevant maternal antenatal factors and associated neonatal outcomes” | |
| Does postnatal breastfeeding support improve rates of breastfeeding? | |
| A cross-sectional study to evaluate the knowledge and uptake of pertussis vaccination in postnatal women at The Northern Hospital | |
| Comparison of neonates receiving nasal Continuous Positive Airways Pressure in tertiary and non-tertiary centres in Victoria | |
| Rising obesity rates and compliance with Australasian recommendations in maternity care: trends in maternal obesity and clinical care of women with BMI > 50 at The Northern Hospital | |
| “Impact of Provision of Preschool Wheeze Action Plan on the Quality of Care in Children less than 6 years old with Wheezing” | |
| Parental attitudes to the free influenza vaccine for children under 5 years | |
| Australasian Maternity Outcomes Surveillance System (AMOSS) | |
| The My Baby’s Movements (MBM) Study | |
| Australian and New Zealand Neonatal Network Register for Clinical Audit | |
| Evaluation of Group Antenatal and Postnatal Care for Refugee Women: Group Pregnancy Care STUDY | |
| Harmonising age pathology parameters in kids (HAPPI Kids) | |
| High-flow nasal cannulae use in non-tertiary centres for early respiratory distress (The HUNTER Trial) | |
| A Phase 2b Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Preterm Infants |
| Clinical Division | Project Title |
| Allied Health | Effective sensory rehabilitation after stroke: Targeting viable train networks (CoNNECT) |
| Expiratory Muscle Strength Training (EMST) versus traditional dysphagia rehabilitation for intervention of dysphagia in Parkinson’s disease in the community setting | |
| Does training family to help with physiotherapy for older people transitioning from hospital to the community increase falls-related self-efficacy? A randomised controlled trial and qualitative analysis. | |
| Functioning the community after inpatient rehabilitation | |
| Improving the Integration and Communication of End of Life Care Services – a Pilot Study | |
| Investigating the safety of a Low Calorie Diet using Optifast as a method of weight loss in obese patients receiving dialysis therapy | |
| Falls and Body Schema Research Project | |
| Effect of eccentrically biased aerobic exercise on quality of life and functional capacity in people with chronic heart failure: a randomised controlled trial. | |
| Retrospective evaluation of a lifestyle intervention program to reduce potentially avoidable hospital admissions and risk factors for metabolic syndrome. | |
| Validation of a dietitian independent novel nutritional assessment tool (DI-NNAT) utilising Computed Tomography (CT) for physical evaluation. Short Title: Dietitian independent novel nutritional assessment tool (DI-NNAT) | |
| Participation in the electronic Persistent Pain Outcomes Collaboration (ePPOC): An initiative to support continuous improvement in the quality and effectiveness of pain management in Australia | |
| The barriers to attendance in heart failure rehabilitation | |
| The utilisation of a clinical reasoning tool for pain by physiotherapists working in hospital and community settings. | |
| Improving the Physical Activity of Cancer Survivors through Wearable Technology – The IMPACT Trial | |
| The success of research implementation strategies on evidence-based decision-making by allied health managers: a randomised controlled trial | |
| Pressure reducing characteristics of offloading devices commonly used to manage diabetes-related foot ulceration | |
| “Implementation of a supervised implementation of a supervised exercise program for patients receiving cytotoxic and anti-cancer chemotherapy” | |
| Investigating the Dietary Habits and the impact of a Mediterranean diet in high risk cardiovascular patients | |
| “Investigating Malnutrition in Victorian Cancer Services: Malnutrition Prevalence Study 2018” |
| Clinical Division | Project Title |
| Other | Austin Health and Northern health clinical staff views on voluntarty assisted dying |
| Point prevalence survey of delirium in Victorian public hospitals | |
| Incidence, Frequency and Attitudes to Code-switching in Interpreted Interactions | |
| HealthLinks: Chronic Care Evaluation | |
| “The Patient Handling Injuries Review of Systems (PHIRES) Toolkit: pilot and implementation trial” | |
| Exploring the communication structures and networks of senior staff in a public hospital’s clinical directorate. | |
| Assessing health practitioners’ knowledge of the Medical Treatment Planning and Decisions Act | |
| Interprofessional Passport Project | |
| Assessing patient safety culture of junior and senior medical staff in a metropolitan teaching hospital | |
| Innovation Implementation in Healthcare: A resource Based View | |
| Investigating the effectiveness of 360 degrees (multi-source) feedback to facilitate Senior Medical Staff performance review. | |
| Evaluation of the Preceptorship Model for La Trobe University Undergraduate Nursing Student Placement at The Northern Hospital | |
| Improving quality of care for patients attending The Northern Hospital or attending Craigieburn Health Service | |
| Hospital Encounters of people with Cognitive Disability |
There are current project and strategic initiatives within Northern Health which you can get involved in as junior doctors.
Current Research Projects at Northern Health
| Clinical Division | Project Title |
| Emergency Services
|
A randomised blind placebo controlled trial of hydrocortisone in critically ill patients with septic shock (ADRENAL) |
| Nebulised heparin for lung injury. A multi-centre, randomised, double blind, placebo controlled trial (CHARLI) | |
| Sedation practice in intensive care evaluation: SPICE III: A prospective multicentre randomised controlled trial of early goal directed sedation compared with standard care in mechanically ventilated partients in intensive care (SPICE) | |
| National study of family experiences of organ and tissue donation (Donor Family Study Waves 2-4) | |
| Proton Pump Inhibitors vs. Histamine-2 REceptor Blockers for Ulcer Prophylaxis Therapy in the Intensive Care Unit (PEPTIC) | |
| The Augmented versus Routine approach to Giving Energy Trial: A randomised controlled trial. (The TARGET Nutrition Study) |
|
| STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRTAKI): A MultiCentre, Randomized, Controlled Trial |
|
| Responding to the needs of Children/Young people visiting patients in the intensive care unit | |
| Factors associated with patients undergoing Medical Emergency Team (MET) review at a metropolitan teaching hospital: a multi-faceted audit of antecedent factors and patient outcomes Short Title:MET Call Audit | |
| Intensive Care outcomes from epidemic asthma following a thunderstrom | |
| Association between Time to Infection Management and In-hospital Mortality in the Northern Hospital ICU | |
| Panadeine Forte Audit | |
| Barriers and facilitators to framing in-hospital goals of patient care: physician’s perceptions – a mixed methods approach. | |
| Monitoring and Evaluation of the Victorian State Trauma System – Victorian State Trauma Registry (VSTORM & VOTOR) | |
| The Victorian Ambulance Cardiac Arrest Register (VACAR) | |
| Knowledge Translation in Australasian Paediatric Acute Care Settings: a multi-centred, cluster, randomised controlled trial comparing a tailored, theory informed Knowledge Translation intervention versus passive dissemination of a bronchiolitis guideline. PREDICT KT Study | |
| Reduction of Oxygen After Cardiac Arrest: The EXACT study | |
| The use of intramuscular ketamine by paramedics in the management of the severely agitated patient | |
| “Exploring the delivery of education in the clinical setting to improve paediatric triage education in Australian emergency departments” | |
| Ed Medicine Screening tool study | |
| Northern Emergency Department Step on Sepsis | |
| Prospective, multi centre, international registry of male and female patients newly diagnosed with atrial fibrillation. GARFIELD-AF | |
| Victorian Cardiac Outcomes Registry (VCOR) | |
| PARAGON – A multicenter, randomized, double-blind, parallel group, active-controlled, study to evaluate the efficacy and safety of LCZ696 compared to valsartan, on morbidity and mortality in heart failure patients (NYHA Class II-IV) with preserved ejection fraction | |
| Victorian Cardiac Outcomes Registry (VCOR) – Heart Failure Snapshot | |
| Colchicine in Patients with Acute Coronary Syndromes – the COPS trial | |
| A clinical evaluation of the Medtronic Polymer-Free drug-eluting stent system in de novo native coronary artery lesions(RevElution) | |
| A phase III, double-blind, randomized placebo-controlled study to evaluate the effects of dalcetrapib on cardiovascular (CV) risk in a genetically defined population with a recent Acute Coronary Syndrome (ACS): The dal-GenE trial DAL-301 (Dal-GenE) | |
| Ivabradine in the prevention of Peri-operative Myocardial Injury (IPMI) | |
| PROTECT-ICD Trial: Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-defibrillator Implantation to Prevent Tachyarrhythmia following Acute Myocardial Infarction | |
| DE novo Combination allopurinolthiopurine vs standard thiopurine in IBD patients Escalating to immunomodulators: a Randomized controlled trial (DECIDER study) |
|
| A phase III randomised, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with preserved Ejection Fraction (HFpEF). |
|
| The COlchicine for COronary Plaque MOdification in Acute Coronary Syndrome study. (COCOMO-ACS) study |
|
| A phase III randomised, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with reduced Ejection Fraction (HFrEF). |
|
| A Phase 3, Multicentre, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome Protocol #: CSL112_3001 [the ApoA-I Event ReducinG in Ischaemic Syndromes II (AEGIS-II) Study | |
| Imaging of Coronary Plaques in Subjects Treated With Evolocumab (HUYGENS) |
|
| Optical Coherence Tomography Assessment for Acute Coronary Events in Type 2 Myocardial Infarction/Myocardial Injury | |
| The Massachusetts General Hospital Optical Coherence Tomography Registry (The MGH OCT Registry) | |
| Improving the quality of emergency care for women with heart attacks |
| Clinical Division | Project Title |
| Medicine and Subacute Services | Identifying risks for Thunderstorm Asthma in Seasonal Allergic Rhinitis (TAISAR) cohort study |
| Does music listening during pulmonary rehabilitation in individuals with chronic obstructive pulmonary disease (COPD) improve outcomes? A mixed methods study | |
| Patients’ Perspectives on the Use of a Pulse Oximeter at home. | |
| Point prevalence of diabetes & hyperglycaemia in hospitalised patients at Northern and Melbourne Health | |
| PREDICT UC: Optimising Infliximab Induction therapy for Acute Severe Ulcerative Colitis – A Randomised Controlled Trial |
|
| I6T-MC-AMAN: A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and. Biologic-Failed Patients with Moderately to Severely Active Ulcerative Colitis (LUCENT 1) |
|
| I6T-MC-AMBG: A Phase 3, Multicentre, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Maintenance Study of Mirikizumab in Patients with. Moderately to Severely Active Ulcerative Colitis (LUCENT 2) |
|
| Australian Stroke Clinical Registry (AuSCR) | |
| Fatigue After Stroke Trial (FAST): A randomised controlled study | |
| ATTUNE- ATrial fibrillation in sTroke: Utility of Neuroimaging Evaluation | |
| Participation in Safe Implementation of Treatments in Stroke (SITS) registry | |
| Retinal small vessel abnormalities and increased vascular risk | |
| The identification of novel genes for inherited renal disease, and understanding how these mutations cause disease: Optimisation of the clinical pathway | |
| Australian Follow-up Tracking and Enhancing Recovery after Acute Kidney Injury (AFTER – AKI) | |
| Early needs assessment of adult patients in acute care (Subacute) | |
| Memory and Mood in OSA treatment study (Subacute) | |
| Reducing the impact of aphasisa in stroke patients & their caregivers a year post onset via a brief early intervention (Subacute) | |
| The impact of health assets on outcomes for hospitalised older adults: Development and validation of a health assets index for hospitalised older adults. | |
| Does Electronic Prescribing Lead to Increased Prescribing Errors in the Elderly? A Pilot Study of Intern Prescribing Accuracy in Electronic versus Manual Systems. (Subacute) |
|
| Preventing Avoidable Hospital Admissions for People with Dementia- An Evaluation of Carer and Staff Perspectives (Subacute) | |
| A Phase II randomised, double-blind, placebo-controlled pilot study to assess the efficacy and safety of BNC210 in hospitalised elderly patients with agitation (Subacute) |
|
| Evaluating and monitoring the Goals of Patient Care Summary (Subacute) | |
| Exploring the needs of informal carers of people with advanced Parkinson’s disease: a pilot study (Subacute) | |
| Effectiveness of a Falls Prevention Intervention in Medical Inpatients Using Lean Thinking Methodology (Subacute) | |
| The association between a secure GEM ward’s aggressive behaviour (RAGE) score and unplanned nursing leave (Subacute) | |
| Resident- to resident elder mistreatment (R-REM) in resifential agend care (Subacute) | |
| Prosthetic joint infection in Australia and New Zealand observational (PIANO) study | |
| Establishing outcomes for people not regularly attending HIV care |
| Clinical Division | Project Title |
| Cancer Services | Establishment of a Tissue Bank to collect, store and distribute data, blood and tissue for ethically approved research projects |
| A Phase III trial evaluating the role of continuous letrozole versus intermittent letrozole following 4 to 6 years of prior adjuvant endocrine therapy for postmenopausal women with hormone receptor positive, node poitive, early stage breast cancer (SOLE trial) | |
| A randomised, multi-center, double-blind phase 3 study of PD-0332991 (oral CDK 4/6 INHIBITOR) plus letrozole versus placebo plus letrozole for the treatment of postmenopausal women with ER (+), HER2 (-) breast cancer who have not reeived any prior systemic anti-cancer treatment for advanced disease. | |
| PALLAS: PALbociclib CoLlaborative Adjuvant Study A randomized phase III trial of Palbociclib with standard adjuvant endocrine therapy versus standard adjuvant endocrine therapy alone for hormone receptor positive (HR+) / human epidermal growth factor receptor 2 (HER2)-negative early breast cancer |
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| LEAD – Lung cancer diagnostic and treatment pathways: a comparison between CALD and Anglo-Australian patients | |
| Establishing a biobank of colorectal and pancreatic cancer models for the pursuit of personalised therapies | |
| Pancreatic cancer: Understanding Routine Practice and Lifting End results (PURPLE) A Prospective Pancreatic Cancer clinical registry | |
| Lung Cancer Clinical Quality Registry | |
| Assessing Predictive and Prognostic Biomarkers in Pancreatic Cancer | |
| Tumour DNA Analysis Informing Adjuvant Chemotherapy in Stage III Colon Cancer: A Multicentre Phase II/III Randomised Controlled Study (DYNAMIC-III) |
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| How oesophageal cancer is diagnosed and treated in Victoria: understanding practice and treatment decisions. | |
| Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Locally Advanced Rectal Cancer: A Multicentre Randomised Study (DYNAMIC-Rectal) |
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| Evaluation of Global Coagulation Assays in patients with active malignancy and/or undergoing chemotherapy | |
| The AvR-CHOP study | |
| Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Stage II Colon Cancer (DYNAMIC II) |
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| Treatment of Recurrent and Advanced Colorectal Cancer (TRACC): A prospective multi-site registry |
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| A Phase 3, Double-blind, Randomized Study of BGB-290 versus Placebo as Maintenance Therapy in Patients with Inoperable Locally Advanced or Metastatic Gastric Cancer that Responded to Platinum-based First-line Chemotherapy | |
| DNA Analysis Informing Adjuvant Chemotherapy in Early Stage Pancreatic Cancer: A Multicentre Randomised Study (DYNAMIC-Pancreas) | |
| Upper Gastrointestianal Cancer Registry | |
| Healthy Living after Cancer (HLaC) – a telephone-delivered healthy lifestyle coaching program for cancer survivors | |
| Evaluation of the implementation of the use of My Cancer Care Record (MY CCR) | |
| A Population-Based Prostate Cancer Outcomes Registry Victoria (PCORVic) | |
| The role of CxBladder in identifying urothelial carcinonma in haematuria patients and it’s place in triaging of cystoscopic investigation of haematuria | |
| BioGrid Australia – Australian Cancer Grid (ACG). | |
| Thrombotic Thrombocytopenic Purpra (TTP) Registry | |
| Response post tyrosine Kinase Inhibitor: assessment of sensitivity and therapeutic response to next line therapy in CML. The Australian RESIST Study | |
| A randomised, double-blind, multi-center study of denosumab compared with zoledronic acide (zometa) in the treathment of bone disease in subjects with newly diagnosed multiple myeloma (Denosumab 90090482) | |
| Myeloma & Related Diseases Registry (MRDR) | |
| Evaluation of new Biomarkers of thrombosis in a normal population as well as anticoagulated and hypercoagulable states | |
| Prospective VTE biomarker Study | |
| Global anticoagulant registry in the FIELD observing treatment and outcomes in patients with treated acute venous thromboembolic events in the real world (GARFIELD-VTE) | |
| An Australian, phase III, multi-centre, randomised trial comparing lenalidomide consolidation Vs no consolidation with chronic lymphocytic leukaemia and residual disease following induction chemotherapy (RESIDUUM (CLL6) | |
| A prospective, open-label, multicenter, randomised phase III trial to compare the efficacy and safety of a combined regimen of obinutuzumab and GDC-0199 (ABT-199) versus obinutuzumab and chlorambucil in previously untreated patients with CLL and coexisting medical conditions | |
| The donation, collection, storage and usage of blood and bone marrow samples for the investigation of CD4+ T cell fate in plasma cell dyscrasia. | |
| Evaluation of global coagulation assay parameters in normal and thrombocytopenic populations | |
| Evaluation of global coagulation assays in patients with High Risk cardiovascular Disease risk factors | |
| The Australasian Leukaemia & Lymphoma Group National Blood Cancer Registry and Biorepository | |
| A Phase III, double-blind, placebo-controlled, multicentre, randomized study of Pracinostat in combination with Azacitidine in patients 18 years with newly diagnosed acute myeloid leukemia unfit for standard induction chemotherapy. |
| Clinical Division | Project Title |
| Surgery | Acupressure for PONV (Stages 2 – 4) |
| Endoscopic Polypectomy on Clopidogrel; a randomized controlled trial | |
| Cyanoacrylate glue vs tacks in fication for laparoscopic inguinal hernia repair | |
| Transition, threshold concepts and troublesome knowledge in medical education: Hurdles in becoming an intern doctor | |
| Is laparoscopy safe in pregnancy? Perioperative and obstetric outcomes of laparoscopic surgeries during pregnancy | |
| Retrospective review of upper gastrointestinal bleeding | |
| Are we choosing wisely at Northern health for inguinal hernia repair? | |
| Barrett’s Oesophagus: Review of patient outcomes and guideline adherence | |
| “Investigation of barriers and areas for improvement in plastic surgery care between General Practices in the Northern catchment and The Northern Hospital.” | |
| Critical Care Use following elective primary hip and Knee joint | |
| Laparoscopic Cholecystectomy Video Assessment Study | |
| A multi-centre survey to evaluate the outpatient clinic experience in surgical education and training using cloud-based resources | |
| Acupressure for peri-surgical care: Implementing effective treatments to improve post-operative nausea and vomiting Short Title: Reducing post-surgical nausea and vomiting | |
| Australian Brest Device Registry (ABDR) | |
| “Clinical outcome and risk factors for failure in patients with a late acute prosthetic joint infection | |
| “Clinical outcome and risk factors for failure in patients with a late acute prosthetic joint infection” | |
| Joint replacement following hip fracture | |
| “Epidemiology, Management and outcomes of Traumatic Knee Dislocations (A VOTOR Report) Short Title: Traumatic Knee Dislocations” | |
| In Vivo Reproducibility of the KneeKG in Patients of Different BMIs | |
| Validation of Satisfaction Visual Analogue Score for Patient Satisfaction in Post Total Knee Arthroplasty Patient. Short Title: Validation of Satisfaction VAS in post TKA patient | |
| Evaluation of Biomet patient specific instrumentation in patients undergoing total shoulder replacement | |
| Patella Stabilisation surgery patient outcome scores | |
| Outcomes of operated ankle fractures treated with early weight bearing vs. Six weeks of plaster. | |
| ANZHFR – Australia & New Zealand Hip Fracture Registry | |
| Ideal positioning of elevated-rim acetabular liners in primary total hip replacements | |
| Knee Kinematics in patellofemoral dislocation patients | |
| Knee Kinematics in patients with ACL tear | |
| Medial pivot versus posterior stabilising total knee prosthesis: a comparison of early clinical and functional outcomes and patient satisfaction | |
| Surgery for Olecranon Fractures in the Elderly: a randomised controlled trial of operative vs. Non-operative treatment (SOFIE) | |
| Northern Health Orthopaedic Outcomes – Hip | |
| Anatomical features of the knee patellofemoural dislocation: An MRI based study | |
| Northern Health Orthopaedic Outcomes – Knee | |
| Prospective outcomes after creation of arteriovenous fistula (POCAF) | |
| TRAMOD | |
| The Perioperative ADministration of Dexamethasone and Infection – The PADDI trial | |
| Reduction Of Chronic Postsurgical Pain with Ketamine ROCKet Trial | |
| Does a correlation exist with either ROTEM or Thrombin Generation Assay and a venous thromboembolism risk assessment chart? The CLOT Study. | |
| “A feasibility study to determine if ROTEM may be used to correlate a postpartum venous thromboembolism risk score” | |
| Binational Colorectal Cancer Audit (VIC) – BCCA (VIC) | |
| Cultural perspectives on colorectal cancer screening and the reporting of bowel symptoms – the Arabic-Australian Story. Short title: Bowel health – the Arabic perspective | |
| The role of deep neuromuscular blockade in an ERAS programme for colorectal surgery. |
| Clinical Division | Project Title |
| Women’s & Children’s Health
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Pilot evaluation of global coagulation assays in maternal and umbilical cord blood |
| Improving management of mastitis in breastfeeding women | |
| THE CROSS-COUNTRY ULTRASOUND STUDY – CROCUS | |
| Harnessing Neuroplasticity to Improve Motor Performance in Infants with Cerebral Palsy: a Pragmatic Randomized Controlled Trial (GAME Trial) |
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| Northern Centre for Health Education and Research (NCHER) Reproductive Health Biobank | |
| Ronald McDonald Family Rooms: Understanding their outcomes for families with hospitalised children | |
| Antenatal corticosteroid therapy – do neonatal outcomes match expectations? The Northern Health experience | |
| “Meconium stained amniotic fluid- how great a risk is it? A population based study in the Northern Region, examining relevant maternal antenatal factors and associated neonatal outcomes” | |
| Does postnatal breastfeeding support improve rates of breastfeeding? | |
| A cross-sectional study to evaluate the knowledge and uptake of pertussis vaccination in postnatal women at The Northern Hospital | |
| Comparison of neonates receiving nasal Continuous Positive Airways Pressure in tertiary and non-tertiary centres in Victoria | |
| Rising obesity rates and compliance with Australasian recommendations in maternity care: trends in maternal obesity and clinical care of women with BMI > 50 at The Northern Hospital | |
| “Impact of Provision of Preschool Wheeze Action Plan on the Quality of Care in Children less than 6 years old with Wheezing” | |
| Parental attitudes to the free influenza vaccine for children under 5 years | |
| Australasian Maternity Outcomes Surveillance System (AMOSS) | |
| The My Baby’s Movements (MBM) Study | |
| Australian and New Zealand Neonatal Network Register for Clinical Audit | |
| Evaluation of Group Antenatal and Postnatal Care for Refugee Women: Group Pregnancy Care STUDY | |
| Harmonising age pathology parameters in kids (HAPPI Kids) | |
| High-flow nasal cannulae use in non-tertiary centres for early respiratory distress (The HUNTER Trial) | |
| A Phase 2b Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Preterm Infants |
| Clinical Division | Project Title |
| Allied Health | Effective sensory rehabilitation after stroke: Targeting viable train networks (CoNNECT) |
| Expiratory Muscle Strength Training (EMST) versus traditional dysphagia rehabilitation for intervention of dysphagia in Parkinson’s disease in the community setting | |
| Does training family to help with physiotherapy for older people transitioning from hospital to the community increase falls-related self-efficacy? A randomised controlled trial and qualitative analysis. | |
| Functioning the community after inpatient rehabilitation | |
| Improving the Integration and Communication of End of Life Care Services – a Pilot Study | |
| Investigating the safety of a Low Calorie Diet using Optifast as a method of weight loss in obese patients receiving dialysis therapy | |
| Falls and Body Schema Research Project | |
| Effect of eccentrically biased aerobic exercise on quality of life and functional capacity in people with chronic heart failure: a randomised controlled trial. | |
| Retrospective evaluation of a lifestyle intervention program to reduce potentially avoidable hospital admissions and risk factors for metabolic syndrome. | |
| Validation of a dietitian independent novel nutritional assessment tool (DI-NNAT) utilising Computed Tomography (CT) for physical evaluation. Short Title: Dietitian independent novel nutritional assessment tool (DI-NNAT) | |
| Participation in the electronic Persistent Pain Outcomes Collaboration (ePPOC): An initiative to support continuous improvement in the quality and effectiveness of pain management in Australia | |
| The barriers to attendance in heart failure rehabilitation | |
| The utilisation of a clinical reasoning tool for pain by physiotherapists working in hospital and community settings. | |
| Improving the Physical Activity of Cancer Survivors through Wearable Technology – The IMPACT Trial | |
| The success of research implementation strategies on evidence-based decision-making by allied health managers: a randomised controlled trial | |
| Pressure reducing characteristics of offloading devices commonly used to manage diabetes-related foot ulceration | |
| “Implementation of a supervised implementation of a supervised exercise program for patients receiving cytotoxic and anti-cancer chemotherapy” | |
| Investigating the Dietary Habits and the impact of a Mediterranean diet in high risk cardiovascular patients | |
| “Investigating Malnutrition in Victorian Cancer Services: Malnutrition Prevalence Study 2018” |
| Clinical Division | Project Title |
| Other | Austin Health and Northern health clinical staff views on voluntarty assisted dying |
| Point prevalence survey of delirium in Victorian public hospitals | |
| Incidence, Frequency and Attitudes to Code-switching in Interpreted Interactions | |
| HealthLinks: Chronic Care Evaluation | |
| “The Patient Handling Injuries Review of Systems (PHIRES) Toolkit: pilot and implementation trial” | |
| Exploring the communication structures and networks of senior staff in a public hospital’s clinical directorate. | |
| Assessing health practitioners’ knowledge of the Medical Treatment Planning and Decisions Act | |
| Interprofessional Passport Project | |
| Assessing patient safety culture of junior and senior medical staff in a metropolitan teaching hospital | |
| Innovation Implementation in Healthcare: A resource Based View | |
| Investigating the effectiveness of 360 degrees (multi-source) feedback to facilitate Senior Medical Staff performance review. | |
| Evaluation of the Preceptorship Model for La Trobe University Undergraduate Nursing Student Placement at The Northern Hospital | |
| Improving quality of care for patients attending The Northern Hospital or attending Craigieburn Health Service | |
| Hospital Encounters of people with Cognitive Disability |